Study of CD117 abundance on ovarian cancer EVs

We are pleased to inform you that our article "Expression level of CD117 (KIT) on ovarian cancer extracellular vesicles correlates with tumor aggressiveness" is published in Frontiers in Cell and Developmental Biology

 In this work, we analyzed the correlation between CD117 expression and the histological type of ovarian tumor.
We have demonstrated that expression of CD117 on tumor cells and its abundance on EVs isolated from cell cultures and body fluids of ovarian cancer patients correlate with tumor type, grade and therapy resistance status. Moreover, using EVs isolated from ovarian cancer ascites, we have shown that recurrent  disease is characterized by a much higher abundance of CD117 on EVs than the primary tumor. The results of our pilot study demonstrate that CD117 profiling on EVs could be potentially used in liquid biopsy tests  for characterization of aggressivity of ovarian tumors.